Actually, psoriasis is a T-cell mediated autoimmune skin disease, IFN-gama, TNF-α, IL-17A, CXCLs, CCLs, and antimicrobial peptide secreted by immune cells or keratinocytes undergo important functions in the crosstalk between keratinocyte and immune cells in the pathogenesis of psoriasis (35–38), thus, in view of the results that we validated in CD4+ T cell with CCNE1, we pay more attention to the correlation analysis between CCNE1 and inflammatory mediators mentioned above, and the results showed that CCNE1 was significantly correlated with IL-17A/CXCL8/CXCL9/CXCL10/CCL20 (P<0.0001, R2>0.3). The gene discussed is TNF; the disease is psoriasis.