However, in the future, we should pay more effort into the validation and investigation of the specific regulatory mechanisms of CCNE1 with CXCL8/9/10 and CCL20, and whether IL-17 can stimulate CCNE1 expression in keratinocytes, CD4+T cells and neutrophils in the pathogenesis of psoriasis, in addition to this, expanded samples are also needed to further improve the sensitivity of the diagnostic genes. The gene discussed is IL17A; the disease is psoriasis.