CCNE1 and psoriasis: Indeed, CCNE1 is a positive regulator of the cell cycle, which can activate cyclin-dependent kinases 2 (CDK2) to regulate the G1-S transition of the cell division cycle, and plays an important role in the regulation of cell cycle progression and cell proliferation (39).To further investigate the role of CCNE1 in psoriasis, we performed immunohistochemical experiments, which showed that CCNE1, as a nuclear protein, was increased in the nuclei of cells in the epidermis of psoriasis relative to normal human skin.