Furthermore, our results show that the genes mediating the development of IBD in psoriasis may be associated with the following genes CSF2RA/SOCS1/PTPN2/STAT3/IL21R (in the Supplementary Table 4), which has implications for the exploration of co-morbid targets in PsO combined with IBD. The gene discussed is PTPN2; the disease is inflammatory bowel disease.