As shown in Figure 6, in adaptive immunization, we first observed a positive correlation between T cells CD4+ memory activated and T cells CD4+ follicular helper in normal skin lesions, non-lesional areas in psoriatic patients, and lesional areas in psoriatic patients, therefore, we speculate that T cells CD4+ memory activated and T cells CD4+ follicular helper might play an indispensable regulatory role throughout the whole process of change from mild to severe process of psoriasis-like skin lesions. The gene discussed is CD4; the disease is psoriasis.