It is a fatal generalized inflammatory response which involves mainly autocrine and paracrine activation of leukocytes, macrophages, endothelial cells, and mast cells, associated with the release for high levels of pro-inflammatory cytokines and chemokines in COVID-19, including IL-2, IL-6, IL-8, IL-10, IL-18, IP-10, CCL 2, IFN-γ, and TNF-α (53, 54). The gene discussed is TNF; the disease is COVID-19.