As one of the most common autoimmune disorders in the world, Hashimoto’s thyroiditis (HT) is characterized by lymphocyte infiltration and thyroid autoantibodies such as against thyroid peroxidase (anti-TPO) or thyroglobulin (anti-TG), which eventually leads to thyroid fibrosis and hypothyroidism (1, 2). The gene discussed is TPO; the disease is Hashimoto thyroiditis.