CoQ10 can restore the expression, activity and nuclear translocation of Nrf2 in GECs cultured with HG, thus upregulating the expression of PINK and parkin, which suggest that CoQ10 act as a potent mitochondrial antioxidant and play a beneficial role in DKD by restoring mitophagy via the Nrf2/ARE signaling pathway (Sun et al., 2019). Here, PRKN is linked to diabetic kidney disease.