PRKN and diabetic kidney disease: SHYS could improve the expression on Parkin, PINK1 and LC3-II protein and reduce the expression of p62, NLRP3, VDAC1, Tom20, and COXIV protein, which suggests that SHYS enhances the mitophagy mediated by Pink1/Parkin pathway and avoids mitochondrial and inflammatory injury to protect renal function from DKD (Li H. et al., 2022).