In a rat model of gastric cancer precancerous lesion (PLGC), the levels of PI3K, p-AKT and HIF-α were significantly upregulated, whereas the levels of PI3K, p-AKT and HIF-α were suppressed after Fufang E’jiao Jiang administration (Shi et al., 2023). Here, AKT1 is linked to gastric cancer.