This review summarizes the animal-derived natural products that have been found to have potential anti-HCC effects, such as cinobufotalin, cinobufagin, bufalin, CTD, NCTD, MCA, beauvericin, etc. These animal-derived products induce cell apoptosis, induce autophagy, reverse drug resistance, inhibit tumor migration, block the cell cycle, and inhibit tumor cell metabolism through various pathways such as PI3K/Akt/mTOR, Ras/ERK/MAPK, Wnt/β-catenin, JAK/STAT, etc., and have extremely high clinical potential. Here, MAPK1 is linked to hepatocellular carcinoma.