Besides NDR2, another study reported that NDR1 activity also increases TNF-α dependent activation of the transcription factor nuclear factor “kappa-light-chain-enhancer” of activated B-cells (NF-κB) in various human tumor cell lines (Shi et al., 2012), supporting the important role of NDR1/2 in the regulation of TNF-α activity. The gene discussed is TNF; the disease is neoplasm.