Lastly, in human tumor cells with high glucose uptake, the O-GlcNAc transferase (OGT) has been shown to O-GlcNacylate YAP and disrupt its interaction with LATS, decreasing YAP-phosphorylation and degradation, therefore increasing YAP-dependent transcription in an AMPK-independent manner. The gene discussed is YAP1; the disease is neoplasm.