ACTA1 and cervical carcinoma: Similar findings have been demonstrated in cervical cancer, where IL-6/STAT3 signalling activates fibroblasts and increases senescence (in CAFs, but not normal fibroblasts) (34), increases in αSMA expression (35), and wider effects on other aspects of the TME include TH17 cells (which may contribute to immunosuppression in the TME (36).