The association between circulating ANGPT2 levels and EV TF-PCA was further confirmed by ROC analysis demonstrating that an ANGPT2 level above 5,000 pg/mL, which has been previously associated with COVID-19 severity (16), could be predicted with an estimated accuracy of 0.92 (CI95% 0.74–1.00; p = 0.04) and 0.84 (CI95% 0.72–0.96; p = 0.02) by EV TF-PCA levels in the subset of patients who required ICU management (Figure 1E), and in the whole study population (patients and healthy individuals) (Figure 1F). The gene discussed is TF; the disease is COVID-19.