Second, although patients with PE or DVT would represent a very interesting group to address this question, the COVID-19 patient cohort served as the basis for our study, and it was decided to use them to address this question because higher ANGPT2 levels in this population are linked to the severity of the disease (and may therefore be involved in its pathogenesis) and also show clinical and laboratory indicators of hypercoagulability. Here, ANGPT2 is linked to thrombophilia.