The signaling pathways involved in T cells and B cells, including Epstein–Barr virus infection, Spliceosome, Intestinal immune network for IgA production, Primary immunodeficiency, TCR signaling pathway, Th17 cell differentiation, and Th1 and Th2 cell differentiation, may indicate a synergistic effect between all immune cells in the peripheral blood of HFRS patients. The gene discussed is CD79A; the disease is inborn error of immunity.