IGHMBP2 and neuropathy: Thus, it is feasible that alternative consequences of IGHMBP2 deletion beyond tRNA or elongation dysregulation may more dominantly contribute to neuropathy and myopathy, although it is appealing to speculate this may be tissue-dependent considering SMARD1 model mice are rescued when expressing a modifier locus encoding ABT1 and five tRNA-Tyr genes (de Planell-Saguer et al, 2009).