It specifically targets rapidly dividing cells, including cancer cells, leading to DNA damage.[30, 31] Cisplatin is platinum‐based chemotherapy drugs, that bind to the DNA strands and cross–links them, preventing the strands from separating and effectively disrupting DNA replication and transcription processes, evenly leading to DNA damage and triggering cell death pathways in colon cancer cells.[32] Hyperactivation of DNA repair may be one of the mechanisms for radio chemoresistance.[22, 23] Here we found that USP25 may regulate radio‐chemoresponse in a set of colon cell lines. Here, USP25 is linked to colonic neoplasm.