Then, we checked the tissue-specific expression of SLC38A4 (where cg14671384 is located) using GTEx [46] and observed that SLC38A4 was significantly overexpressed in liver, which is a tissue highly relevant to obesity and the change of body weight (Fig. 4B) [47]. Here, SLC38A4 is linked to obesity due to melanocortin 4 receptor deficiency.