The LVMs did not reveal a statistically significant association between SLC6A4 or TPH2 methylation and 5-HTTLV or 5-HT4LV in the healthy cohort nor the cohort of MDD patients (unadjusted p-values ranged between 0.06 and 0.97; Table 2). The gene discussed is SLC6A4; the disease is major depressive disorder.