Collectively, this research elucidates the complex interplay between DR3, TL1A, and associated signaling adaptors in prion disease, shedding light on their potential roles in prion disease specific motor deficits possibly by affecting cortico-striatal neuronal pathways (Additional file 1: Fig. S4B) and thereby laying the groundwork for future explorations in prion disease mechanisms and therapeutic strategies. The gene discussed is TNFSF15; the disease is prion disease.