Conversely, the deficiency in TRADD and TRAF2 might weaken neuronal and oligodendrocyte cell survival pathways while amplifying TNFα-TNFR1-RIPK1-FADD-caspase-8 mediated cell death pathways, presenting a complex landscape of cellular fate determination in prion disease pathology. Here, TNFRSF1A is linked to prion disease.