BIN2 and Alzheimer disease: Additionally, CD33m+ microglia had decreased levels of proteins such as Bin2 (Bridging integrator 2) that is abundant in AD brains and associated with amyloid-driven neuroinflammation [54], and Rac2 (Rac family small GTPase-2) that is associated with detrimental effects of inflammatory response in microglia such as apoptosis [55].