In high-fat, low-methionine, and choline-deficient (HFLMCD) diet-induced nonalcoholic steatohepatitis (NASH) mouse model, liver-specific E4bp4 knockout (E4bp4-LKO) mice present a lower degree of lipid droplet accumulation in the liver and a better liver function compared with those of E4bp4flox/flox mice [34]. The gene discussed is NFIL3; the disease is metabolic dysfunction-associated steatohepatitis.