Then, the following candidate genes ranked in descending order according to their relative impact on the development or severity of microtia: PRKDC > LEPR > PLG > MUC6 > DGKK > GPR161 > WDR36 > BPTF > LRBA > SOD3 > KCNQ4 (Fig. 2A). The gene discussed is PLG; the disease is microtia.