We identified rhythmically expressed genes, which have been associated with developmental processes, such as hydrocephalus-associated genes (Ccdc88c, Hydin) [53, 96], and several rhythmically expressed mitogens, which are likely diurnally released into CSF (Wnt5b, Angpt1-2, Ccn2) [97–99]. Here, HYDIN is linked to Hydrocephalus.