PSEN2 and Alzheimer disease: For example, the gene for interleukin 33 (Il33), which plays a role in reversing the buildup and preventing the new formation of amyloid plaques in animal AD model APP/PS1 mice [102], Lrp8os3, coding for the receptor for AD genetic risk marker apolipoprotein E [103], or Fhl2, coding adaptor protein physically interacting with another important AD marker, presenilin 2 [104].