RenalNext® test, a next-generation sequencing panel, was used to test 20 cancer susceptibility genes for hereditary kidney cancer: BAP1, CHEK2, EPCAM, FH, FLCN, MET, MLH1, MSH2, MSH6, MITF, PMS2, PTEN, SDHA, SDHB, SDHC, SDHD, TP53, TSC1, TSC2, and VHL. The test identified a 5’UTR deletion in the TSC1 gene, a likely pathogenic variant. Here, TSC1 is linked to cancer.