With the evidence of phytocanabinoids, affecting neuroblastoma cells lines, we decided to examine Cannabis extracts, isolated Phyto cannabinoids and their hemisynthetic derivates on the non-differentiated SHSY5Y neuroblastoma cells to gain knowledge about its effect on cell viability and caspases 3/7 activation, as a marker of apoptosis induction. The gene discussed is CASP3; the disease is neuroblastoma.