Our study links the pathogenesis of periodontitis with the ferroptosis pathway, building a bridge through the bioinformatics-predicted key genes SLC1A5, SLC2A14, LURAP1L, and HERPUD1.Existing research indicates that periodontal tissue in periodontitis exhibits dysregulation of iron-containing compounds such as ferritin, transferrin, and heme [44, 45]. The gene discussed is SLC1A5; the disease is periodontitis.