Previous mouse gene augmentation studies using AAV expressing human CRB2 have shown both morphological and functional rescue in CRB-associated RP mouse models (Crb1Crb2F/+ cKO, Crb2Chx10 cKO, and Crb1KOCrb2LowMGC), suggesting the great potential of AAV mediated gene augmentation therapies for CRB patients [71, 104]. This evidence concerns the gene CRB2 and retinitis pigmentosa 1.