Conditional disruption of one allele of CRB2 in PRCs on a Crb1−/− genetic background (Crb1KOCrb2Low − immPRC mice) produced an RP-like phenotype, whereas conditional full ablation of CRB2 in PRCs on a Crb1−/− genetic background (Crb1KOCrb2ΔimmPRC mice) resulted in a phenotype similar to that of LCA [70]. The gene discussed is CRB1; the disease is Leber congenital amaurosis.