CRB1 and Leber congenital amaurosis: In summary, the complete loss of CRB1 in CRB1KO and CRB1KOCRB2+/− retinal organoids leads to more extensive degeneration of both inner and outer retina, mimicking a mild form of LCA, whereas the CRB1 patients-derived retinal organoids express reduced level of CRB1 variants and show only degeneration of outer retina.