Ablation of CRB1 and CRB2 mimicked the LCA, whereas the retinas in the single heterozygote Crb1+/−Crb2 cKO displayed intermediate phenotypes between the Crb2Chx10 cKO and the double homozygote Crb1Crb2 cKO [31, 69]. This evidence concerns the gene CRB2 and Leber congenital amaurosis.