DDX53 and neoplasm: The results showed that only Cyclo(-RGDfK) did not impact efferocytosis of apoptotic tumor cells by macrophages, but when combined with CT26-EVs or MC38-EVs, it reversed the efferocytosis effect induced by the CRC-EVs (including CT26-EVs and MC38-EVs) (Fig. 5A and B).