STAT3 and colorectal carcinoma: As shown in Fig. 7A and D, we found that intraperitoneal injection of CRC-EVs led to an increase in the expression of αvβ3 (as indicated by the percentage of APC-αvβ3-positive population within FITC-F4/80-positive population analyzed through flow cytometry, Fig. 7A and B) and elevated phosphorylation levels of STAT3 (measured by the immunofluorescence intensity of p-STAT3 in F4/80 staining using confocal microscopy, Fig. 7C and D) in peritoneal macrophages of mice.