For example, the combined application of curcumin with cisplatin effectively inhibits CRC through MicroRNA-137-Glutaminase axis [4]; Arctigenin increased the sensitivity of CRC resistant to cisplatin through the activation of autophagy [5]; And metformin up-regulated the sensitivity of CRC to cisplatin by activating PI3K/Akt pathway [6]. This evidence concerns the gene AKT1 and colorectal carcinoma.