NUPR1 and hepatocellular carcinoma: Functional assays demonstrated that NUPR1 could also rescue the inhibitory effect on proliferation and migration caused by miR-455-3p overexpression in HCC cells (Supplementary Fig. 4A-C), and the promoting effect on cell proliferation and migration by depletion of miR-455-3p was reversed by ZZW-115 administration (Supplementary Fig. 4D-F).