Furthermore, cell proliferation and migration abilities were rescued by NUPR1 overexpression in sh-circPIAS1 HCC cells (Supplementary Fig. 1A-C), while administration of ZZW-115 partially mitigated the aggressive phenotypes induced by circPIAS1 overexpression, as revealed by functional assays (Supplementary Fig. 1D-F). This evidence concerns the gene NUPR1 and hepatocellular carcinoma.