Xia et al. reported that on the one hand, hypoxia could promote the expression of miR-301a-3p and release of miR-301a-3p-enriched exosomes by GC cells; on the other hand, exosomes can then transfer miR-301a-3p to recipient GC cells to inhibit HIF-1α degradation through targeting prolyl-hydroxylase 3 (PHD3) [129]. This evidence concerns the gene EGLN3 and gastric cancer.