PTEN and non-small cell lung carcinoma: In addition, it has been demonstrated that CAFs-derived exosomes can promote the progression and chemoresistance of non-small cell lung cancer (NSCLC) by delivering miR-20 to target PTEN in recipient cells, suggesting that TME can also be harnessed by cancer cells to abrogate the inhibitory effect of PTEN on PI3K signaling [105].