In glioma, a truncated and oncogenic form of the epidermal growth factor receptor (EGFR), known as EGFRvIII, was demonstrated to be present in microvesicles derived from tumour cells; these microvesicles can then transfer EGFRvIII to neighbour cells to activate downstream AKT signalling [99]. The gene discussed is EGFR; the disease is central nervous system cancer.