While M1-like TAMs activated by exosome-transferred thrombospondin-1 (THBS1) have been demonstrated to promote malignant migration in oral squamous cell carcinoma (OSCC) by Xiao et al. [93], the same research group provided further evidence supporting that M1-like TAMs can cascade a mesenchymal/stem-like phenotype of OSCC via the IL6/Stat3/THBS1 feedback loop [94]. This evidence concerns the gene THBS1 and oral cavity squamous cell carcinoma.