Recently, an AS1411-functionalized pH‐responsive biogenic titanium dioxide nanoparticles (TNP) was developed for targeted co-delivery of Forkhead box protein M1 (FOXM1) aptamer and DOX and enhanced therapeutic efficacy against breast cancer was demonstrated both in vitro and in vivo [407], suggesting that similar strategy may also be explored in developing aptamer-guided exosome delivery system. The gene discussed is FOXM1; the disease is breast carcinoma.