However, also in CRC, CAFs-derived exosomal lncRNA FAL1 was evidenced to act as a scaffold for the interaction between Beclin1 and TRIM3 to promote TRIM3-dependent Beclin1 polyubiquitination and degradation, thereby suppressing oxaliplatin-induced autophagic cell death [347]. Here, BECN1 is linked to colorectal carcinoma.