Through the analysis of the TCGA online database, we foundthat the expression level of CD276 in ccRCC tumor tissues was significantlyhigher than that in normal kidney tissues, both in non-paired samples and pairedsamples (Fig. 1A–B).Similarly, upon examining the HPA online database, we observed that CD276 washighly expressed in ccRCC tissues, while it was lowly expressed in normal kidneytissues (Fig. 1C). This evidence concerns the gene CD276 and nonpapillary renal cell carcinoma.