Neuronal death in neurodegenerative diseases like AD and Parkinson's disease (PD) is associated with the nuclear translocation, aggregation, and binding of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) to toxic proteins such as β-amyloid peptides, tau protein, and α-synuclein18. Here, YWHAQ is linked to neurodegenerative disease.