Our data revealed that HSP70 inhibition significantly reduced the progression of both PANC-1 and MIA PaCa-2 tumor xenografts when mice were treated every other day with 10 mg/kg of AP-4-139B, compared to vehicle alone (Fig. 5H, Supplementary Fig. 5A); this was confirmed by tumor volumes and tumor weights at endpoint for both xenograft models (Fig. 5I, Supplementary Fig. 5B, C). Here, HSPA1A is linked to neoplasm.