The functional significance underpinning this differential regulation of NONO and FUS vs SFPQ is unclear; however, SFPQ activates the cytoplasmic RIG-I stress response with increases in IFNβ production [55], which is of interest in that this pathway is induced by MUC1-C in cancer cells in association with chronic inflammation, DNA damage resistance and immune evasion [38, 46]. The gene discussed is RIGI; the disease is cancer.