A total of 161 pathways were obtained from the analysis of KEGG pathways, and 132 (P < 0.01) entries were significantly correlated, among which the PI3K- Akt, MAPK, mTOR, Insulin, Insulin resistance, and Apoptosis signaling pathway are considered to be the core pathways of QGQXM for DCM treatment. This evidence concerns the gene AKT1 and familial dilated cardiomyopathy.