For instance, recent reports have highlighted how such genes as DCTN1 (dynactin 1) [97–99], GDAP1 (ganglioside-induced differentiation-associated protein 1) [97, 100, 101], DYNC1H1 (Dynein, cytoplasmic 1, heavy chain 1) [102, 103], KIF5A (Kinesin Heavy Chain Isoform 5A) [102, 104], and NEFH (neurofilament heavy chain gene) [105, 106] have been associated with a wide range of phenotypes, ranging from ALS to HSP [107], dSMA or even classic Charcot–Marie–Tooth disease [97, 102, 103, 108–110]. The gene discussed is KIF5A; the disease is hereditary spastic paraplegia.