Numerous studies have investigated the use of different fecal biomarkers for CMA diagnosis, including fecal IgA, EDN, eosinophilic cationic protein (ECP), and fecal calprotectin (FC).17 Unfortunately, studies regarding fecal EDN in non-IgE-mediated CMA children are controversial and intestinal permeability appears to interact with the composition of the microbiota, which has been implicated in the development of food allergies.47 fEDN level was higher in CMA patients compared to controls.1,17 Although this finding seems promising, these differences were not statistically significant. Here, IGHE is linked to food allergy.