These findings concluded that APP transcript variants-based, differentiated state-sensitive marker system could be used to effectively characterize the advanced stages of differentiated SH-SY5Y-derived neuronal cells, demonstrating a "true maturity." To the best of our knowledge, this is among the most comprehensive studies on SH-SY5Y differentiation with respect to the expression of the AD central gene, APP. Here, APP is linked to Alzheimer disease.