Among patients with MPRT and a diagnosed hereditary cancer syndrome, multiple CRCC was reported in patients with VHL disease (93.5% (43/46)) and constitutional chromosome 3 translocations (100% (5/5) and multiple PRCC in those with germline MET protooncogene mutations (95.2% (20/21)). This evidence concerns the gene MET and chromophobe renal cell carcinoma.