For example, MPRT in VHL disease is almost exclusively clear cell whereas type 1 papillary RCC is seen in HPRC (Table 1) and histopathological analysis can be supplemented by immunohistochemistry to identify specific characteristics of a cancer syndrome such as loss of FH expression and overexpression of 2-SC in HLRCC and loss of SDHB immunostaining in SDH-deficient RCC [26]. Here, SDHB is linked to hereditary leiomyomatosis and renal cell cancer.