PBRM1 and renal cell carcinoma: Multiple other genes have been reported to potentially predispose to RCC, including PBRM1, BRIP1, CDKN2B, DCLRE1B/Apollo, MITF and NBR1, but are not routinely tested in clinical practice as they appear to be rare causes of inherited RCC/MPRT and/or require additional confirmation of RCC risks [36–40].