Some histological subtypes are associated with characteristic molecular findings in the tumour (e.g. chromosome 3 loss and inactivation of the VHL tumour suppressor gene (TSG) in CRCC, copy number gains of chromosome 7 and activating MET protooncogene alterations in Type 1 hereditary papillary renal carcinoma (HPRC)) whereas other molecular alterations (e.g. mutations in FLCN, SETD2, TP53 genes) can be a feature of both CRCC and non-CRCC subtypes [4, 5]. This evidence concerns the gene SETD2 and chromophobe renal cell carcinoma.