The number of genes within a panel may be as few as six (e.g. BAP1, FH, FLCN, MET, SDHB, and VHL genes) though commercial genetic testing companies may offer larger gene panels (18–30 genes but including some for non-RCC kidney tumours; (Supplementary Table 3)). The gene discussed is SDHB; the disease is renal cell carcinoma.