Two further phaeochromocytoma/paraganglioma (PPGL) predisposition genes, TMEM127 and MAX, have also been linked with RCC predisposition and, whilst not routinely tested for, might be investigated if they are in a patient with MPRT and a personal or family history of PPGL without evidence of a germline mutation on routine testing [41]. Here, TMEM127 is linked to renal cell carcinoma.