However not all the CSGs harbouring a PGV were known to be associated with predisposition to RCC (only 4.5% of all cases had a PGVs in a CSG (VHL, FLCN, MET, TSC1/2, FH, SDHA/B/C/D, BAP1 and CHEK2) recognised as being associated with RCC predisposition) [18]. The gene discussed is SDHA; the disease is renal cell carcinoma.