For example, the ‘MHC class II protein complex’ was significantly enriched for genes overlapping T2D and GERD (PAdj = 5.87 × 10−4), gastritis-duodenitis (PAdj = 3.00 × 10−3), IBS (PAdj = 7.77 × 10−5), diverticular disease (PAdj = 1.98 × 10−3), and IBD (PAdj = 2.56 × 10−7) [Supplementary Data 52–54, and 56–57]. Here, HLA-DQA1 is linked to gastroesophageal reflux disease.