We next evaluated by flow cytometry 37 primary and 5 patient-derived xenograft γδ T-ALL samples from a Hôpital Necker Enfants-Malades (Paris, France) cohort, identifying two cases with CD8β surface expression (Fig. 6b), one of which overexpressed TLX3. This evidence concerns the gene TLX3 and acute lymphoblastic leukemia.