FOXO1 and chronic obstructive pulmonary disease: In conclusion, through bioinformatics analysis and experimental verification, this study revealed that FOXO1 and DDX17 may be related to regulatory genes of T cells in the immune-inflammatory responses of thelung tissue of COPD patients, thus which providing a scientific basis for studying the changes in the immune microenvironment of lung tissue after chronic cigarette smoke exposure and more potential immunotherapy targets.