It’s worth noting that AF127577.4 lncRNA, which encodes the AF127577.4-ORF, significantly associates with higher GBM grade and reduced patient survival, whilst the AF127577.4-ORF micropeptide encoded by the same lncRNA is negatively correlated to GBM grade and reduces both cell proliferation and ERK activation and also increases cell death. The gene discussed is MAPK1; the disease is glioblastoma.