METTL3 and glioblastoma: AF127577.4-ORF functions as a suppressor of GBM cell proliferation in vitro by diminishing the stability of m6A writer methyltransferase like 3 (METTL3), a pro-tumorigenic player in GBM by elevating RNA m6A methylation13,14, via its modulation of the ERK2/METTL3 interaction.