Moreover, in bladder urothelial carcinoma (BLCA), colon adenocarcinoma (COAD), kidney chromophobe (KICH), kidney renal clear cell carcinoma (KIRC), rectum adenocarcinoma (READ), and stomach adenocarcinoma (STAD), AKR1B10 expression levels showed a decreasing trend compared to normal tissues (Fig. 1c). The gene discussed is AKR1B10; the disease is colon adenocarcinoma.