As shown in Table 3, univariate analysis revealed that tumor status (HR = 2.317, P < 0.001), pathological grading (HR = 2.504, P < 0.001), T stage (HR = 2.598, P < 0.001), M stage (HR = 4.077, P = 0.017), and AKR1B10 expression (HR = 1.711, P = 0.002) were significantly related to overall survival (OS) of liver cancer patients. This evidence concerns the gene AKR1B10 and liver cancer.