Another transcription factor, NF-κB, has been shown to play different roles at different stages of liver disease: in the early stages of chronic liver disease, the activation of NF-κB may help promote inflammatory responses and cell proliferation, leading to liver tissue damage and fibrosis; as the disease progresses, the overactivation of NF-κB may lead to the malignant transformation of hepatocytes, thereby promoting the development of liver cancer. This evidence concerns the gene NFKB1 and liver cancer.