Another large-scale multicenter study followed 273 newly diagnosed HCC patients for two years, finding that serum AKR1B10 levels were significantly related to tumor stage, size, the number of primary tumors, and Child–Pugh classification, and HCC patients with high serum AKR1B10 levels had a significantly lower median survival than those with normal levels33. Here, AKR1B10 is linked to hepatocellular carcinoma.