SMAD7 and liver cancer: Another study at the cellular level confirmed that miR-216a-5p restoration rescued A1BG-AS1 attenuated proliferation, migration and invasion of hepatocellular carcinoma.To be specific,A1BG-AS1 positively regulated the levels of phosphatase and tensin homolog and SMAD family member 7, which were reduced by miR-216a-5p in HCC cells43.Recent studies have found that DANCR is significantly upregulated in liver cancer tissues, and high levels of DANCR expression are associated with tumor staging, lymph node metastasis, and prognosis in liver cancer patients44.