This suggests that by regulating AKR1B10, the metabolic state of immune cells can be affected, thereby affecting their immune killing effect on liver cancer cells, providing insights into the potential immune regulatory role of AKR1B10 in HCC, highlighting its involvement in the regulation of the tumor microenvironment and immune cell responses, but further experimental research is needed to clarify the underlying mechanisms driving these correlations and their potential implications in immune regulation and disease. Here, AKR1B10 is linked to hepatocellular carcinoma.