To identify genes associated with AKR1B10 and significantly related to the prognosis of liver cancer, we intersected the top 354 genes most strongly correlated with AKR1B10 (absolute correlation coefficient ≥ 0.3) with 5035 upregulated survival-related genes in LIHC (p Cox < 0.05), resulting in 160 AKR1B10 prognostic-related genes (Fig. 6d). Here, AKR1B10 is linked to liver cancer.