AKR1B10 and hepatocellular carcinoma: Multiple studies have confirmed that in patients infected with hepatitis C virus (HCV)34 and hepatitis B virus (HBV)35, high expression of AKR1B10 is an independent prognostic factor predicting HCC development, and AKR1B10 may even be a molecular marker reflecting the progression from steatohepatitis to HCC36.