In summary, high expression of AKR1B10 is closely associated with clinicopathological features in hepatocellular carcinoma, and may promote development and influence prognosis by activating inflammation-related signaling pathways and altering the tumor immune microenvironment through the DANCR-miR-216a-5p-AKR1B10 axis. This evidence concerns the gene AKR1B10 and neoplasm.