To preliminarily clarify the mechanism of action of AKR1B10 in HCC, we further used the GEPIA2 database to extract genes most strongly correlated with AKR1B10 for GSEA enrichment analysis, showing that AKR1B10 mainly interacts with TOLL-like receptors, NOD-like receptors, KEAP1/NFE2L2, and NF-κB transcription factors. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.