Current animal experiments have shown that it has a good effect on myocardial fibrosis in CHF, which may be related to reducing the expression of collagen genes (collagen type I alpha 1 chain, collagen type III alpha 1 chain), and its beneficial effect on the cardiac function of mice undergoing transverse aortic constriction (TAC) surgery remains unchanged even after treatment is interrupted29. This evidence concerns the gene COL3A1 and Myocardial fibrosis.