COL3A1 and congestive heart failure: Current animal experiments have shown that it has a good effect on myocardial fibrosis in CHF, which may be related to reducing the expression of collagen genes (collagen type I alpha 1 chain, collagen type III alpha 1 chain), and its beneficial effect on the cardiac function of mice undergoing transverse aortic constriction (TAC) surgery remains unchanged even after treatment is interrupted29.