Replication analyses using data from the FinnGen study suggested that APOB (OR = 1.63, 95% CI 1.15–2.29, P = 5.60 × 10−4) modified by HMGCR were associated with an increased risk of migraine, but LDL levels (OR = 1.19, 95% CI 0.91–1.56, P = 0.20) and TC levels (OR = 1.21, 95% CI 0.95–1.53, P = 0.12) modified by HMGCR were not significantly associated with an increased risk of migraine (Fig. 2, Supplementary Table 6). Here, HMGCR is linked to migraine disorder.