HMGCR and migraine disorder: The supplementary analyses suggested that genetically predicted levels of LDL (OR = 1.51, 95% CI 1.21–1.88, P = 2.50 × 10−4), TC (OR = 1.63, 95% CI 1.30–2.06, P = 2.93 × 10−5), and APOB (OR = 2.12, 95% CI 1.56–2.87, P = 1.35 × 10−6) modified by HMGCR were associated with an increased risk of migraine (Fig. 2, Supplementary Table 6).