To evaluate the innate immune response to infection in more detail, we performed a comparative gene expression analysis of genes encoding the following: interferons and pro-inflammatory cytokines (Ifng, Ifnk, Il1b, Il6, Il18, and Tnf), transcription factors involved in immunity and inflammation (Irf1, Irf3, Irf7, Nfkb1, and Stat1), interferon-stimulated genes (ISGs) (Ifi6, Ifi27l1, Ifitm1, Isg15, Isg20, Ly6e, Mx1, Mx2, Oas1, Oas2, Oas3, and Oasl), and pattern recognition receptors or nucleic acid sensors (Ifih1, Nlrp3, and Sting1). The gene discussed is ISG15; the disease is infection.