C5AR1 and neoplasm: Mrc1, Msr1, Ccl8, Il10, Siglec1 that have been associated with pro-tumor activity, pro-tumor cytokine production, anti-inflammatory, phagocytosis and checkpoint activities59,60 were significantly positively correlated with C5ar1 expression and latent-time as were the Msr1, Mrc1, Mcl1, Ccl8, Il10 and Siglec1 pro-tumor markers with protumor cytokine production, anti-inflammatory, phagocytosis and checkpoint activities61 (Fig. 6B).