To directly test whether C5aR1 macrophages from T127 were involved in the transfer of resistance to T22 in the co-transplantation model, we isolated C5aR1hi cells (that are mainly TAM_C3 from the blood of T127 tumor-bearing mice and transferred them to T22 tumor-bearing mice (Supplementary Fig. 6G). Here, C5AR1 is linked to neoplasm.