TAM_C3, characterized by Mrc1 and Pf4 DEGs, was enriched for expression genes associated with pro-tumor activity including anti-inflammatory, phagocytosis and checkpoint activities35 as well as KEGG lipid related pathway and GO type I interferon-related pathway activity (Supplementary Fig. 1H, I and Supplementary Fig. 2A). This evidence concerns the gene PF4 and neoplasm.