Consistently with TAM_C3, C5ar1_hi_C3 was dominantly associated with a worse outcome in TCGA basal breast cancer (Supplementary Fig. 3F) and when assessing contributions of cluster top DEG to outcomes in TCGA basal breast cancer by multivariate analysis, C5AR1 was associated with poor outcomes independently (Supplementary Fig. 3G). The gene discussed is C5AR1; the disease is breast cancer.