Notably, both exemplary studies reported their findings in the cancer context where ectopic HACE-1 expression enhances autophagy to inhibit the growth of human lung cancer xenografts, while the genetic deletion of TRIM27 is also associated with enhanced autophagy inhibiting tumor initiation in the PyMT murine mammary tumor model but conversely promoting metastasis. The gene discussed is HACE1; the disease is lung carcinoma.