Phenotypic analysis of TIICs revealed that (while there was no significant difference in the number of NK cells, M1, and M2 macrophages between DRG2-depleted tumors and wild-type tumors) the number of IFN-γ-expressing CD8+ T cells was significantly increased in DRG2-depleted tumor compared with wild-type tumors (Fig. 1C and Supplementary Fig. S1). The gene discussed is DRG2; the disease is neoplasm.