The currently available diagnostic tools for periodontal diseases primarily rely on clinical and radiographic findings, reflecting past disease events only.71 In this context, various research approaches emphasize the importance of using biomarkers in the study of periodontitis.28,72 Indeed, due to their relevance to the etiopathogenesis of periodontal disease, MMP-8 and IL-6 have been extensively employed in periodontitis studies. Here, MMP8 is linked to periodontitis.