In a recent research, which used a similar bioinformatic approach to identify cell clusters and explore the expression of different genes associated with cell death, specific genes associated with ferroptosis, pyroptosis, and necroptosis were observed in periodontitis patients compared with healthy controls.94 Collectively, the observed variations in IL-6, FTH1 and DCN abundance levels between NP and PG groups, combined with the alignment of DEPs with scRNA-seq gene expression levels, indicate a significant susceptibility of fibroblast to undergo ferroptosis during periodontitis progression. The gene discussed is FTH1; the disease is periodontitis.