For instance, TRPML1-mediated lysosomal Zn2+ release induces mitochondrial dysfunction and necrotic cell death in metastatic melanoma cells [43], while lysosomal Ca2+ release through TRPML1 is implicated in multiple lysosomal-related processes such as lysosomal trafficking, autophagy, and organelle interactions [44]. The gene discussed is MCOLN1; the disease is metastatic melanoma.