S100A1 and neoplasm: We found that the genes significantly expressed in spatial domain 1 (IDC_4) participated in the process of tumor formation, invasion and metastasis (CCND1, S100A1, AGR2 and GFRA1), tumor inhibition (CXCL14) and cytoskeleton formation and regulation (KRT8 and TTLL12) (Figure S8d-left) [36].