Numerous central nervous system diseases, including PNCDs, are correlated to the onset of perioperative stress-induced central neuroinflammation [50], with nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3 (NLRP3) inflammasome-mediated neuroinflammation, and microglial activation being key factors in exacerbating these diseases [75]. Here, NLRP3 is linked to central nervous system disorder.